Professor Jim Camakaris

Recent Publications 1998 - 2006

Norgate M, Lee E, Southon A, Farlow A, Batterham P, Camakaris J, Burke R. Essential Roles in Development and Pigmentation for the Drosophila Copper Transporter DmATP7. Mol Biol Cell. 17: 475-484 (2006)

D'Amico, F, Skarmoutsou E, Sanfilippo, S, and Camakaris, J. Menkes protein localization in rat parotid acinar cells. Acta Histochemica 107: 373-378 (2005)

Greenough, M., Pase, L., Voskoboinik, I., Petris, M.J., Wilson-O'Brien, A., and Camakaris, J. Signals regulating trafficking of the Menkes copper-translocating P-type ATPase in polarised MDCK cells. Am. J. Physiol. (Cell Physiol) 287 (5): C1463 - 1471 (2004)

Bellingham, S. A., Lahiri, D. K., Maloney, B., La Fontaine, S., Multhaup, G., Camakaris, J. Copper depletion down-regulates expression of Alzheimer's disease Amyloid-beta precursor protein gene. J. Biol. Chem. 279: 20378 - 20386 (2004)

Bellingham, S., Ciccotosto, G., Needham, B., Fodero, L., White, A., Masters, C., Cappai, R., and Camakaris, J. Gene knockout of Amyloid Precursor Protein and Amyloid Precursor-like Protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J.Neurochemistry 91: 423-428 (2004)

Southon, A., Burke, R., Norgate, M., Batterham, P., and Camakaris, J., Copper homeostasis in Drosophila melanogaster S2 cells. Biochemical Journal 383: 303 - 309 (2004)

Hussain, D., Haydon, M.J., Wang, Y., Wong, E., Sherson, S.M., Camakaris, J., Harper, J.F., and Cobbett CS. P-type ATPase heavy metal transporters with roles in essential zinc homeostasis in Arabidopsis. The Plant Cell 16: 1327 - 1339 (2004)

Voskoboinik, I., and Camakaris, J. "P-type pumps: Copper pump" In "Encyclopeadia of Biological Chemistry". (ed Lennarz and Lane). Vol 3, 561 - 564, Academic Press (2004)

Pase, L., Voskoboinik, I., Greenough, M., and Camakaris, J. Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool. Biochem. J. 378: 1031-1037 (2004)

Lane, C., Petris, M., Benmerah, A., Greenough, M., and Camakaris, J. Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (ATP7A;MNK) Biometals 17: 87-98 (2004)

Voskoboinik, I., Fernando, R., Veldhuis, N., Hannan, K.M., Marmy-Conus, N., Pearson, R.B., and Camakaris, J. Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase. Biochem. Biophys. Res. Commun. 303: 337-342 (2003) (b)

Voskoboinik, I., Mar, J., and Camakaris, J. Mutational analysis of the Menkes copper P-type ATPase (ATP7A). Biochem. Biophys. Res. Comm. 301: 488-494 (2003) (a)

Voskoboinik, I., Camakaris, J., and Mercer, J.F. Understanding the mechanism and function of copper P-type ATPases. Adv. Protein Chemistry Vol. 60 (Valentine, J. and Gralla, E. Eds) pp. 123-150 Elsevier Science, USA (2002)

Voskoboinik, I., and Camakaris, J. Menkes copper-translocating P-type ATPase (ATP7A): Biochemical and Cell Biology properties. J. Bioenergetics and Biomembranes 34: 363- 371 (2002)

Petris, M.J., Voskoboinik, I., Cater, M., Smith, K., Kim. B.E., Llanos, R.M., Strausak, D., Camakaris, J. and Mercer, J.F. Copper-regulated trafficking of the Menkes disease copper-ATPase is associated with formation of a phosphorylated catalytic intermediate. J. Biol. Chem. 277: 46736-46742 (2002)

Mercer, J.F.B., Kramer, D. and Camakaris, J. Molecular basis of diseases of copper homeostasis, Handbook of copper pharmacology and toxicology (E. Massaro Ed.) pp. 249-276. Humana Press NJ. USA (2002)

Lockhart, P.J., Fontaine, S.L. Firth, S.D., Greenough, M., Camakaris, J. and Mercer, J.F.B. Correction of the copper transport defect of Menkes patient fibroblasts by expression of two forms of the sheep Wilson ATPase. Biochemica et Biophysica Acta. 1588: 189-94 (2002)

Burlando, B., Evangelisti, V., Dondero, F., Pons, G., Camakaris, J., and Viarengo, A. Occurrence of a Cu-ATPase in Dictyostelium: possible role in resistance to copper. Biochem. Biophys. Res. Commun. 291: 476-483 (2002)

Voskoboinik, I, Mar, J., Strausak, D. And Camakaris, J. The regulation of Catalytic activity of the Menkes Copper-translocating P-type ATPase, J. Biol. Chem 276: 28620- 28629 (2001) (b)

Voskoboinik, I., Greenough, M., La Fontaine, S., Mercer, J.F.B., and Camakaris, J. Functional studies on the Wilson copper P-type ATPase and Toxic Milk Mouse mutant, Biochem. Biophys. Res. Commun. 281: 966-970 (2001) (a)

Borchardt, T., Schmidt, C., Camakaris, J., Cappai, R., Masters, C.L., Beyreuther, K., Multhaup, G. Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells. Cell Mol. Biol. 46: 785-95 (2000)

White, AR, Multhaup, G, Maher, F, Bellingham, S, Camakaris, J, Zheng, H, Bush, A I, Beyreuther, K, Masters, CL, Cappai, R. The Alzheimer’s Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures.
J. Neurosci. 19: 9170-9179 (1999).

White, AR, Reyes, R, Mercer, JFB, Camakaris, J, Zheng, H, Bush, AI, Multhaup, G, Beyreuther, K, Masters, CL, Cappai, R. Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res. 842: 439-444 (1999).

Voskoboinik, I, Strausak, D, Greenough, M, Brooks, H, Petris, M, Smith, S, Mercer, JF, Camakaris, J. Functional Analysis of the N-terminal CXXC Metal-binding Motifs in the Human Menkes Copper-transporting P-type ATPase Expressed in Cultured Mammalian Cells. J. Biol. Chem. 274: 22008-22012 (1999).

Petris, M.J., Mercer, J.F.B. and Camakaris, J.The cell biology of the Menkes disease proteins. In "Proceedings of a Satellite Meeting of the European Human Genetics Society on Copper Transport and its Disorders: Molecular and Cellular Aspects". Eds. A. Leone and J.F.B. Mercer. Kluwer Academic/Plenum Publishers, New York. Chapter 5, pp. 53-66 (1999).

Firth, SD, Lockhart, PJ, Brooks, H, Camakaris*, J, Mercer*, JF. Intracellular localization and loss of copper responsiveness of Mnk, the murine homologue of the Menkes protein, in cells from blotchy (Mo blo) and brindled (Mo br) mouse mutants. Hum. Mol. Genet. 8: 1069-1075 (1999). *These authors made equal contributions.

Camakaris, J, Voskoboinik, I, Mercer, JF, Lane, C, Parton, R, Petris, M, Stausak, D. The copper transporting P-type ATPase of Menkes disease. J. Inorg. Biochem. 74: 15 (1999).

La Fontaine S, Firth, S.D., Lockhart, P.J., Brooks, H., Camakaris, J. and Mercer J.F.B. Intracellular localisation and loss of copper responsiveness of MNK, the murine homologue of the Menkes protein, in cells from blotchy (Mo blo) and brindled (Mo br) mouse mutants. Human Molecular Genetics, 8: 1069-1075 (1999)

La Fontaine, S., Firth, S.D., Lockhart, P.J., Brooks, H., Camakaris, J. and Mercer, J.F.B. Functional analysis of the Menkes protein (MNK) expressed from a cDNA construct. In "Proceedings of a Satellite Meeting of the European Human Genetics Society on Copper Transport and its Disorders: Molecular and Cellular Aspects". Eds. A. Leone and J.F.B. Mercer. Kluwer Academic/Plenum Publishers, New York. Chapter 6, pp. 67-82 (1999).

Delatycki M.B., Camakaris, J., Brooks, H., Evans-Whipp, T., Thorburn, D.R., Williamson, R. and Forrest, S. M. Direct evidence that mitochondrial iron accumulation occurs in Friedreich Ataxia. Annals of Neurology, 45: 673-675 (1999)

Camakaris, J., Voskoboinik, I. and Mercer, J.F. Molecular mechanisms of copper homeostasis. Biochemical and Biophysical Research Communications, 261: 225-232 (1999)

Borchardt, T, Camakaris, J, Cappai, R, Masters, CL, Beyreuther, K, Multhaup, G. Copper inhibits b -amyloid production and stimulates the non-amyloidogenic pathway of amyloid precursor protein (APP) secretion. Biochem. J. 344: 461-467 (1999).

Voskoboinik I, Brooks, H, Smith, S, Shen, P & Camakaris, J.ATP-dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured CHO cells. FEBS Lett. 435: 178-182 (1998).

Petris MJ, Camakaris*, J, Greenough, M, La Fontaine, S & Mercer*, JFB 1998. A C-terminal di-leucine is required for localisation of the Menkes protein in the trans-Golgi network. Hum. Mol. Genet. 7: 2063-2071 (1998). *these authors made equal contributions.

La Fontaine S, Firth, SD, Lockhart, PJ, Brooks, H, Parton, RG, Camakaris, J & Mercer, JFB. Functional analysis and intracellular localisation of the human Menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1). Hum. Mol. Genet. 7: 1293-1300 (1998).

La Fontaine S, Firth, SD, Camakaris, J, Englezou, A, Theophilos, MB, Petris, MJ, Lockhart, PJ, Greenough, M, Brooks, H, Reddell, RR & Mercer, JFB. Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases. J. Biol. Chem. 273: 31375-31380 (1998).

Mercer, J.F.B. and Camakaris, J. Menkes and Wilson diseases: Genetic disorders of copper transport. In "Metal Ions in Gene Regulation". Eds. W.Walden and S. Silver. pp 250-276 Chapman & Hall (NY) (1998)