Associate Professor Meryl Davis

Recent Publications 1995 - 2007

Wong, K.H., Hynes, M.J., Todd, R.B., and Davis, M.A. (2007) Transcriptional control of nmrA by the bZIP transcription factor MeaB reveals a new level of nitrogen regulation in Aspergillus nidulans. Molecular Microbiology. 66(2): 534-551.

Hynes, M.J., Szewczyk, E., Murray, S.L., Suzuki, Y., Davis, M.A., and Sealy-Lewis, H.M. (2007) Transcriptional Control of Gluconeogenesis in Aspergillus nidulans. Genetics. 176:139–150.

Todd, R.B., Davis, M.A., and Hynes, M.J. (2007) Genetic manipulation in Aspergillus nidulans: meiotic progeny for genetic analysis and strain construction. Nature Protocols. 2(4): 811-821. (Journal cover picture).

Todd, R.B., Davis, M.A., and Hynes, M.J. (2007) Genetic manipulation in Aspergillus nidulans: heterokaryons and diploids for complementation, dominance and haploidization analyses. Nature Protocols. 2(4): 822-830.

Michael J.Hynes, Sandra L. Murray, Anna Duncan, Gillian Khew Su-Wen and Meryl A.Davis (2006). Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus, Aspergillus nidulans. Eukaryot. Cell 5: 794-805.

Monahan BJ, Askin MC, Hynes MJ and Davis MA (2006). Differential expression of Aspergillus nidulans ammonium permease genes is regulated by GATA transcription factor AreA. Eukaryot. Cell 5: 226-237.

Todd, R.B., Fraser, J.A., Wong K.H., Davis, M.A., and Hynes, M.J. (2005) Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export. Eukaryotic Cell. 4(10): 1646-1653.

Davis MA, Askin MC, Hynes MJ. Amino acid catabolism by an areA-regulated gene encoding an L-amino acid oxidase with broad substrate specificity in Aspergillus nidulans. Appl Environ Microbiol. (2005) 71(7):3551-5.

Polotnianka R, Monahan BJ, Hynes MJ, Davis MA. TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans. Mol Genet Genomics. (2004) 272:452-9.

Hynes,M.J. and Davis, M.A. ( 2004). Regulation of the amdS gene in  Aspergillus nidulans.  in The Mycota III. Biochemistry and Molecular Biology, 2nd Edition. R.Brambl and G.A.Marzluf (Eds.) Springer-Verlag, Berlin. Book chapter.

Monahan, B.J., Unkles, S.E., I, T.T., Kinghorn, J.R., Hynes, M.J. and Davis, M.A. (2002) Mutation and functional analysis of the Aspergillus nidulans ammonium permease MeaA and evidence for interaction with itself and MepA. Fungal Genet. Biol. 36: 35-46

Fraser, J.A., Davis, M.A. and Hynes,M.J.(2002) A gene from Aspergillus nidulans with similarity to URE2 of S. cerevisiae encodes a glutathionine S-transferase which contributes to heavy metal and xenobiotic resistance. Appl. Environmental Microbiol. 68: 2802-2808

Hynes, M.J., Draht,O.W. and Davis, M.A. (2002) Regulation of the acuF gene encoding phosphenolpyruvate carboxykinase in the filamentous fungus Aspergillus nidulans J.Bacteriol. 184: 183-190

Monahan, B.J., Fraser, J.A., Hynes, M.J. and Davis, M.A. (2002) Isolation and characterisation of two ammonium permease genes, meaA and mepA, from Aspergillus nidulans. Euk. Cell 1: 85-94

Fraser, J.A., Davis, M.A. and Hynes, M. J. (2002). The genes gmdA, encoding an amidase, and bzuA, encoding a cytochrome p450, are required for benzamide utilization in Aspergillus nidulans. Fungal Genetics and Biology 35: 135-146

Tanaka, A., Kamei, K-I., Tanoue, S., Papagiannopoulos, P. Steidl, S., Brakhage. A.A., Davis, M.A., Hynes, M.J., Kato. M., Kobayashi, T. and Tsukagoshi, N. (2001). AohapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the corresponding subunits in Aspergillus nidulans. Curr. Genet. 39: 175-182

Szewczyk, E., Andrianopoulos, A, Davis, M.A. and Hynes, M.J (2001). A single gene produces mitochrondrial, cytoplasmic and peroxisomal NADP-dependent isocitrate dehydrogenase in Aspergillus nidulans. J. Biol. Chem. 276: 37722-37729

Margelis, M., D'Souza, C., Small, A. J., Hynes, M.J., Adams, T.H. and Davis, M.A. (2001). The role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans. J. Bacteriol. 183: 5826-5833

Small, A. J., Todd, R. B., Zanker, M. C., Delimitrou, S., Hynes, M. J. and Davis, M.A. (2001). Functional analysis of TamA, a co-activator of nitrogen regulated gene expression in Aspergillus nidulans. Mol. Genet. Genomics 265: 636-646

Fraser, J, A. Davis, M A. and Hynes, M. J. (2001). The formamidase gene of Aspergillus nidulans: regulation by nitrogen metabolite repression and transcriptional interference by an overlapping upstream gene. Genetics 157: 119-131

Tanaka, A., Kato, M., Hashimoto, H., Kamei, K., Naruse, F., Papagiannopoulos, P., Davis, M.A., Hynes, M.J., Kobayashi, T. and Tsukagoshi, N. (2000). An Aspergillus oryzae CCAAT-binding factor, AoCP, is involved in the high level expression of the Taka-amylase A gene. Curr Genet. 37: 380-387

Narendja, F. M., Davis, M. A. and Hynes, M. J. (1999). AnCF, the CCAAT binding complex of Aspergillus nidulans, is essential for the formation of a DNaseI-hypersensitive site in the 5’ region of the amdS gene. Mol. Cell. Biol. 19: 6523-6531

Small, A. J., Hynes, M. J. and Davis, M. A. (1999). The TamA protein fused to a DNA binding domain can recruit AreA, the major nitrogen regulatory protein, to activate gene expression in Aspergillus nidulans. Genetics 153: 95-105

Brakhage, A.A., Andrianopoulos, A., Kato, M. , Steidl, S., Davis, M.A., Tsukagoshi, N. and Hynes, M. J. (1999). HAP-like CCAAT-binding complexes in filamentous fungi: Implications for biotechnology. Fungal Genet. Biol. 27: 243-252

Steidl, S., Papagiannopoulos, P., Litzka ,O., Andrianopoulos, A., Davis, M.A., Brakhage, A.A. and Hynes, M. J. (1999). AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR. Mol. Cell. Biol. 19: 99-106

Macheda, M., Hynes, M. J. and Davis, M.A. (1999). The Aspergillus nidulans gltA gene encoding glutamate synthase is required for ammonium assimilation in the absence of NADP-glutamate dehydrogenase. Curr. Genet. 34: 467-471

Stemple, C.J., Davis, M.A. and Hynes, M.J. (1998) The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase. J. Bacteriol 180: 6242-6251

Litzka, O., Papagiannopoulos, P., Davis, M.A., Hynes, M.J. and Brakhage, A.A. (1998) The penicillin regulator PENR1 of Aspergillus nidulans is a HAP-like transcriptional complex. Eur. J. Biochem. 251: 758-767

Christensen, T., Hynes, M.J. and Davis, M.A. (1998). The role of the areA gene of Aspergillus oryzae in nitrogen metabolism. Appl. And Envir. Microbiol. 64: 3233-3237

Kato, M., Aoyama, A., Naruse, F., Tateyama, Y., Hayashi, K., Miyazaki, M., Papagiannopoulos, P., Davis, M.A., Hynes, M.J., Kobayashi, T. and Tsukagoshi, N. (1998) The Aspergillus nidulans CCAAT-binding factor AnCP/AnCF, is a heteromeric protein analogous to the HAP complex of Saccharomyces cerevisiae. Molec.Gen. Genet. 257: 404-411

Andrianopoulos, A., Kourambas, S., Sharp, J.A., Davis, M.A. and Hynes, M.J. (1998) Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression. J. Bacteriol 180: 1973-1977

Todd, R.B., Andrianopoulos, A., Davis, M.A., and Hynes, M.J. (1998) FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences. EMBO J. 17 101-113

Davis, M.A. and Hynes, M.J. (1997) Why are nit-2 transformants of Aspergillus nidulans partially derepressed? Fungal Genetics Newsletter 44 13-14

Andrianopoulos, A., Brons, J., Davis, M.A. and Hynes, M.J. (1997) The amdA regulatory gene of Aspergillus nidulans ; characterization of gain-of -function mutations and identification of binding sites for the gene product. Fungal Genetics and Biology 1 50-63

Murphy, R.L., Andrianopoulos, A., Davis, M.A. and Hynes, M.J. (1997) Identification of amdX, a new C2H2 zinc finger gene involved in the regulation of the amdS gene of Aspergillus nidulans. Molec. Microbiol. 23 591-602

Todd, R.B., Murphy, R.L., Martin, H.M., Sharp,J.A., Davis, M.A., Katz, M.E. and Hynes, M.J. (1997). The acetate regulatory gene facB of Aspergillus nidulans encodes a Zn(II)2Cys6 transcriptional activator. Molec.Gen.Genet. 254 495-504

Davis, M.A., Small, A., Kourambas, S. and Hynes, M.J. (1996). The tamA gene ofAspergillus nidulans contains a putative zinc finger cluster motif which is not required for gene function. J.Bacteriol. 178 3406-3409

Papagiannopoulos, P., Andrianopoulos, A., Sharp, J.A., Davis, M.A. and Hynes, M.J.(1996). The hapC gene of Aspergillus nidulans is involved in the expression of CCAAT-containing promoters. Molec.Gen.Genet. 251 412-421

Straffon, M.J., Hynes, M.J. and Davis, M.A. (1996). Characterization of the ugatA gene of Ustilago maydis, isolated by homology to the gatA gene of Aspergillus nidulans. Curr. Genet. 29 360-369

Hynes, M.J. and Davis, M.A. (1996). Regulation of acetamide catabolism. In ‘The Mycota’ Vol. IV’ eds R.Brambl and G.A.Marzluf Springer-Verlag, Berlin

Lints, R., Davis, M.A. and Hynes, M.J. (1995). A chromosome walk linking the gatA and alcCgenes of Aspergillus nidulans. Fungal Genetics Newsletter 42: 44-45

Lints, R., Davis, M.A. and Hynes, M.J. (1995). The positively acting amdA gene of Aspergillus nidulans encodes a protein with two C2H2 zinc finger motifs. Mol.Microbiol. 15: 965-975

Bonnefoy, N., Copsey, J., Hynes, M.J. and Davis, M.A. (1995). Yeast proteins can activate expression through regulatory sequences of the amdS gene of Aspergillus nidulans. Mol. Gen. Genet. 246: 223-227

Williams, R.S.B., Davis, M.A. and Howlett, B.J. (1995). The nitrate and nitrite reductase-encoding genes of Leptosphaeria maculans are closely linked and transcribed in the same direction. Gene 158 : 153-154