Research

Mechanisms of Copper Homeostasis

Professor Jim Camakaris

Heavy metals in the environment pose a significant health risk. The heavy metal, copper, is unique in that it is essential for living cells in trace amounts, yet in higher amounts is potentially very toxic. Copper is essential for the healthy functioning of bone, arteries and the central nervous system. Our research studies are directed to understanding the biological systems which have evolved to allow sufficient copper to be available where needed and to prevent build up of high toxic levels. We intend to identify and characterise relevant genes and proteins. Our "tools" are cultured human, animal and yeast cells with mutant genes which disturb copper metabolism.

The broad significance of the work is in providing models for heavy metal detoxification and in understanding inherited and acquired diseases of copper metabolism.

Project A: Structure-function study of mammalian copper transporting P-type ATPases

Project B: Subcellular localisation and trafficking of the Menkes (MNK; ATP7A) copper translocating P-type ATPase

Project C: Copper Homeostasis in Drosophila

Project D: Copper and Alzheimer's Disease

Recent Publications

Camakaris Lab Personnel